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Zepbound users lost nearly 50% more weight than those on Wegovy in first head-to-head study


Published on 2025-05-12 06:46:33 - Fortune
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  • That's according to the study funded by Eli Lilly, which was published Sunday in the New England Journal of Medicine.

In a groundbreaking head-to-head study, Eli Lilly's Zepbound was found to be significantly more effective for weight loss than Novo Nordisk's Wegovy, with Zepbound users losing 50% more weight on average. The study, which involved over 1,800 participants with obesity or overweight and related health issues, showed that after 32 weeks, those on Zepbound lost an average of 18.4% of their body weight, compared to 12.4% for those on Wegovy. Both drugs are weekly injections and belong to a class of medications known as GLP-1 receptor agonists, but Zepbound also targets another hormone, GIP, which may contribute to its superior weight loss results. The findings, presented at the American Diabetes Association's annual meeting, could influence future treatment choices for obesity and related conditions.

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[ https://fortune.com/article/zepbound-users-lost-50-more-weight-wegovy-first-head-to-head-study/ ]